Famotidine polymorphic transformation in the grinding ...
The raw material of famotidine form B powder (water content: 0.07%, w/w) was respectively ground for 30 min in an oscillatory ball mill (Mixer Mill MM301, Retsch & Co., Germany) at an oscillation frequency of 20 Hz. Each 0.2 g form B powder was placed in a 10 ml volume agate milling jar containing two 10 mm diameter agate balls.